Mathematical Model of Fibrin Polymerization
نویسندگان
چکیده
منابع مشابه
Mathematical Model of Fibrin Polymerization
Blood clotting system (BCS) modelling is an important issue with a plenty of applications in medicine and biophysics. The BCS main function is to form a localized clot at the site of injury preventing blood loss. Mutual influence of fibrin clot consisting mainly of fibrin polymer gel and blood flow is an important factor for BCS to function properly. The process of fibrin polymer mesh formation...
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The formation of a fibrin clot is initiated after the proteolytic cleavage of fibrinogen by thrombin. The enzyme removes fibrinopeptides A and B and generates fibrin monomer which spontaneously polymerizes. Polymerization appears to occur though the interaction of complementary binding sites on the NH2-terminal and COOH-terminal (Fragment D) regions of the molecule. A peptide has been isolated ...
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ژورنال
عنوان ژورنال: Mathematical Modelling of Natural Phenomena
سال: 2011
ISSN: 0973-5348,1760-6101
DOI: 10.1051/mmnp/20116705